Back to Search
Start Over
Lung squamous cell carcinoma with brachial soft tissue metastasis responsive to gefitinib: Report of a rare case.
- Source :
-
Thoracic cancer [Thorac Cancer] 2016 Nov; Vol. 7 (6), pp. 676-680. Date of Electronic Publication: 2016 Jun 13. - Publication Year :
- 2016
-
Abstract
- Metastasis of lung cancer to soft tissue is rare and patient outcomes are generally poor. There are no reports describing soft tissue metastasis in lung squamous cell carcinoma (SCC), in which gefitinib treatment was effective not only for the primary tumor but also the metastatic lesion. A 61-year-old Asian woman presented to our facility with pain and a mass in the brachium. An additional tumor was identified in the lung. As we suspected soft tissue metastasis of lung cancer, an incisional biopsy was performed, yielding a diagnosis of SCC. The brachial tumor continued to grow and became exposed at the biopsy site when the incisional wound dehisced. Because the biopsied specimen was positive for an epidermal growth factor receptor (EGFR) gene mutation, we commenced gefitinib administration. This treatment resulted in the rapid shrinkage of both the brachial metastasis and the primary tumor, followed by healing of the wound. Therefore, tyrosine kinase inhibitors should be used for cases that present EGFR activating mutations independently from the presence of skin and soft tissue metastases.<br /> (© 2016 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.)
- Subjects :
- Carcinoma, Squamous Cell genetics
ErbB Receptors genetics
Female
Gefitinib
Humans
Lung Neoplasms genetics
Middle Aged
Mutation
Quinazolines therapeutic use
Soft Tissue Neoplasms genetics
Soft Tissue Neoplasms secondary
Treatment Outcome
Arm pathology
Carcinoma, Squamous Cell drug therapy
Lung Neoplasms drug therapy
Quinazolines administration & dosage
Soft Tissue Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1759-7714
- Volume :
- 7
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Thoracic cancer
- Publication Type :
- Report
- Accession number :
- 27755795
- Full Text :
- https://doi.org/10.1111/1759-7714.12366