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Development and characterization of the voriconazole loaded lipid-based nanoparticles.
- Source :
-
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2017 Jan 05; Vol. 132, pp. 184-189. Date of Electronic Publication: 2016 Oct 01. - Publication Year :
- 2017
-
Abstract
- The number of topical fungal infections is growing, mostly owing to immunosuppressive therapy. Several topical fungal infections, such as eye mycoses, can be treated by local administration of antimycotic drugs. One major group of the antifungal agents is triazole, such as voriconazole (VCZ), which is used as the first line treatment of aspergillosis. A disadvantage of VCZ is its low water solubility making the drug difficult to administer in a liquid preparation. The lipid-based nanoparticles (LNP) have attracted increasing attention due to their advantageous properties. Contrarily to the conventional carrier systems, LNP can improve the poor solubility of topically used drugs, such as VCZ. Therefore, LNP represents promising alternatives to traditional carrier systems. The aim of the study was to formulate VCZ loaded lipid-based nanoparticles (VCZ-LNP) by high pressure homogenization (HPH). The developed LNPs were characterized by particle size analysis, IR spectroscopy, differential scanning calorimetry, dialysis test and antifungal efficacy studies. The particle size of the optimized nanoparticles from the selected lipid base, Witepsol <superscript>®</superscript> W35, was 182±4.1nm after five cycles of homogenization at 600bar. The antifungal study confirmed that the optimized VCZ-LNP inhibited the fungus reproduction.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Antifungal Agents chemistry
Aspergillosis drug therapy
Calorimetry, Differential Scanning
Drug Delivery Systems
Lipids chemistry
Particle Size
Pressure
Reproducibility of Results
Serum Albumin chemistry
Solubility
Spectroscopy, Fourier Transform Infrared
Temperature
Voriconazole analysis
Nanomedicine methods
Nanoparticles chemistry
Voriconazole chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-264X
- Volume :
- 132
- Database :
- MEDLINE
- Journal :
- Journal of pharmaceutical and biomedical analysis
- Publication Type :
- Academic Journal
- Accession number :
- 27750101
- Full Text :
- https://doi.org/10.1016/j.jpba.2016.09.047