Mixed epithelial and stromal tumor of the middle ear: The first case report.

Authors :: Michal M
Skálová A
Kazakov DV
Pecková K
Heidenreich F
Grossmann P
Michal M
Source :: Human pathology [Hum Pathol] 2017 Mar; Vol. 61, pp. 199-204. Date of Electronic Publication: 2016 Oct 13.
Publication Year :: 2017
Abstract: We report a tumor arising in the middle ear of a 65-year-old female patient that was composed of an ovarian-type stroma (OS) and an epithelial component. The tumor consisted of irregular, polypoid masses containing multiple variably sized cystic spaces, which were invariably surrounded by the OS. The cystic spaces were lined by flat, cuboidal, or columnar epithelial cells, in most parts showing mucinous differentiation. The epithelial lining of the cysts strongly expressed cytokeratins AE1-3, CK7, CK8, CK18, CK19, EMA, and S100 protein. The stroma expressed CD34 and smooth muscle actin. No cytological atypia or mitoses were present, and the proliferative activity was less than 1% in both components. The clonality analysis proved the clonal nature of the neoplasm. We believe that this tumor is a new member in the family of neoplasms containing the OS, and therefore we propose the term mixed epithelial and stromal tumor of the middle ear.<br /> (Copyright © 2017 Elsevier Inc. All rights reserved.)