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Searching for the Perfect Homeostasis: Five Strains of Bifidobacterium longum From Centenarians Have a Similar Behavior in the Production of Cytokines.
- Source :
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Journal of clinical gastroenterology [J Clin Gastroenterol] 2016 Nov/Dec; Vol. 50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015, pp. S126-S130. - Publication Year :
- 2016
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Abstract
- Goals: To investigate the modulation of human cytokines by Bifidobacterium longum strains isolated from Centenarians. In particular, we measured the production of interleukin (IL)-12p70, interferon-γ, IL-17A, and IL-4 from human peripheral blood mononuclear cells after stimulation with live bacteria.<br />Background: Probiotics may inhibit pathogens and modulate the immune system, bringing a beneficial effect on human health. Among the probiotic strains, bifidobacteria play a key role in the maturation of the host's immune system. At present, only a few comparative data are available on the effects of bifidobacteria associations on cytokine production.<br />Study: Peripheral blood mononuclear cells were isolated, cultured, and stimulated (ratio 1:1) with B. longum DLBL07, B. longum DLBL08, B. longum DLBL09, B. longum DLBL10, or B. longum DLBL11, either alone or in association. Cytokine production was determined by an enzyme-linked immunosorbent assay.<br />Results: Both the B. longum DLBL mixture and the individual B. longum DLBL strains induced similar levels of IL-4, interferon-γ, and IL-17A. Under all conditions tested, no IL-12p70 release was detected.<br />Conclusions: The fact that B. longum strains were obtained from Centenarians suggests a perfect homeostasis between this specific species and the host. Moreover all the B. longum strains from Centenarians used in our study share some biological similarities.
- Subjects :
- Aged, 80 and over
Enzyme-Linked Immunosorbent Assay
Humans
Interferon-gamma biosynthesis
Interleukin-12 biosynthesis
Interleukin-17 biosynthesis
Interleukin-4 biosynthesis
Leukocytes, Mononuclear microbiology
Bifidobacterium longum physiology
Cytokines biosynthesis
Gastrointestinal Microbiome physiology
Homeostasis physiology
Leukocytes, Mononuclear physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1539-2031
- Volume :
- 50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015
- Database :
- MEDLINE
- Journal :
- Journal of clinical gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 27741155
- Full Text :
- https://doi.org/10.1097/MCG.0000000000000678