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Association of single nucleotide polymorphisms of APOBEC3G with susceptibility to HIV-1 infection and disease progression among men engaging in homosexual activity in northern China.
- Source :
-
Archives of virology [Arch Virol] 2017 Jan; Vol. 162 (1), pp. 259-268. Date of Electronic Publication: 2016 Oct 11. - Publication Year :
- 2017
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Abstract
- Men who have sex with men (MSM) are at high risk of HIV infection. The APOBEC3G (apolipoprotein B mRNA editing catalytic polypeptide 3G) protein is a component of innate antiviral immunity that inhibits HIV-1 replication. In the present study, a total of 483 HIV-1 seropositive men and 493 HIV-1 seronegative men were selected to investigate the association between single nucleotide polymorphisms (SNPs) of the APOBEC3G gene and susceptibility to HIV-1 infection and AIDS progression among MSM residing in northern China. Genotyping of four SNPs (rs5757465, rs3736685, rs8177832, and rs2899313) of the APOBEC3G was performed using the SNPscan™ Kit, while the rs2294367 polymorphism was genotyped using the SNaPshot multiplex system. Our results disclosed no association between the SNPs of APOBEC3G and susceptibility to HIV-1, or effects of these polymorphisms on the CD4 <superscript>+</superscript> T cell count or clinical phase of disease. A meta-analysis of 1624 men with HIV-1 infection and 1523 controls suggested that the association between rs8177832 and susceptibility was not significant. However, we observed a trend towards association with HIV-1 infection for haplotype TTACA (p = 0.082). The potential role of variants of APOBEC3G in HIV-1/AIDS warrants further investigation.
- Subjects :
- Adolescent
Adult
Aged
CD4 Lymphocyte Count
China
Disease Progression
Genotyping Techniques
HIV Infections immunology
HIV Infections pathology
Homosexuality, Male
Humans
Male
Middle Aged
Young Adult
APOBEC-3G Deaminase genetics
Genetic Predisposition to Disease
HIV Infections genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1432-8798
- Volume :
- 162
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 27730383
- Full Text :
- https://doi.org/10.1007/s00705-016-3080-8