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Role of adenosine A2b receptor overexpression in tumor progression.
- Source :
-
Life sciences [Life Sci] 2016 Dec 01; Vol. 166, pp. 92-99. Date of Electronic Publication: 2016 Oct 08. - Publication Year :
- 2016
-
Abstract
- The adenosine A2b receptor is a G-protein coupled receptor. Its activation occurs with high extracellular adenosine concentration, for example in inflammation or hypoxia. These conditions are generated in the tumor environment. Studies show that A2b receptor is overexpressed in various tumor lines and biopsies from patients with different cancers. This suggests that A2b receptor can be used by tumor cells to promote progression. Thus A2b participates in different events, such as angiogenesis and metastasis, besides exerting immunomodulatory effects that protect tumor cells. Therefore, adenosine A2b receptor appears as an interesting therapeutic target for cancer treatment.<br /> (Copyright © 2016. Published by Elsevier Inc.)
- Subjects :
- Adenosine analysis
Adenosine genetics
Adenosine immunology
Adenosine A2 Receptor Antagonists pharmacology
Adenosine A2 Receptor Antagonists therapeutic use
Animals
Disease Progression
Humans
Immune Tolerance drug effects
Molecular Targeted Therapy methods
Neoplasms drug therapy
Neoplasms immunology
Receptor, Adenosine A2B analysis
Receptor, Adenosine A2B immunology
Tumor Microenvironment drug effects
Gene Expression Regulation, Neoplastic drug effects
Neoplasms genetics
Neoplasms pathology
Receptor, Adenosine A2B genetics
Up-Regulation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0631
- Volume :
- 166
- Database :
- MEDLINE
- Journal :
- Life sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27729268
- Full Text :
- https://doi.org/10.1016/j.lfs.2016.10.008