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SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse.
- Source :
-
Cancer cell [Cancer Cell] 2016 Oct 10; Vol. 30 (4), pp. 505-507. - Publication Year :
- 2016
-
Abstract
- In this issue of Cancer Cell, Ferone et al. demonstrate that SOX2 not only drives lung tumor formation but also restricts tumor lineage to squamous cell carcinoma (LSCC), regardless of cell of origin. This novel LSCC model should facilitate identification of key oncogenic drivers and treatment strategies for this lung cancer subtype.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 27728797
- Full Text :
- https://doi.org/10.1016/j.ccell.2016.09.012