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A Naturally Occurring Antibody Fragment Neutralizes Infectivity of Diverse Infectious Agents.
- Source :
-
Scientific reports [Sci Rep] 2016 Oct 11; Vol. 6, pp. 35018. Date of Electronic Publication: 2016 Oct 11. - Publication Year :
- 2016
-
Abstract
- A phosphorylated peptide, named K40H, derived from the constant region of IgMs was detected in human serum by liquid chromatography coupled to high-resolution mass spectrometry. Synthetic K40H proved to exert a potent in vitro activity against fungal pathogens, and to inhibit HIV-1 replication in vitro and ex vivo. It also showed a therapeutic effect against an experimental infection by Candida albicans in the invertebrate model Galleria mellonella. K40H represents the proof of concept of the innate role that naturally occurring antibody fragments may exert against infectious agents, shedding a new light upon the posthumous role of antibodies and opening a new scenario on the multifaceted functionality of humoral immunity.
- Subjects :
- Anti-Infective Agents blood
Anti-Infective Agents chemistry
Anti-Infective Agents pharmacology
Chromatography, Liquid
Humans
Immunoglobulin Fc Fragments chemistry
Immunoglobulin Fc Fragments pharmacology
Mass Spectrometry
Microbial Sensitivity Tests
Peptide Fragments blood
Peptide Fragments chemistry
Peptide Fragments pharmacology
Phosphorylation
Virus Replication drug effects
Candida albicans drug effects
HIV-1 drug effects
Immunoglobulin Fc Fragments blood
Immunoglobulin M chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 27725769
- Full Text :
- https://doi.org/10.1038/srep35018