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Diffusion-weighted imaging of nasopharyngeal carcinoma to predict distant metastases.
- Source :
-
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery [Eur Arch Otorhinolaryngol] 2017 Feb; Vol. 274 (2), pp. 1045-1051. Date of Electronic Publication: 2016 Oct 08. - Publication Year :
- 2017
-
Abstract
- Our study aimed to identify diffusion-weighted imaging (DWI) parameters obtained from primary nasopharyngeal carcinoma (NPC) at initial presentation, that can predict patients at risk of distant metastases. One hundred and sixty-four patients underwent pretreatment magnetic resonance imaging and DWI. The apparent diffusion coefficient (ADC) <subscript>mean</subscript> , ADC <subscript>skewness</subscript> , and ADC <subscript>kurtosis</subscript> were obtained by histogram analysis. Univariate and multivariate analyses of these ADC parameters together with primary volume (PV), nodal volume (NV), T stage, N stage and presence of locoregional relapse (LRR) were compared between patients with distant metastases (DM+) and patients without distant metastases (DM-) at 5 years using logistic regression. Twenty-eight out of 164 patients (17.1 %) were DM+ (2.5-60 months) and 136/164 patients were DM- (61.2-119.4 months). Compared to DM- patients, the primary tumour of DM+ patients showed significantly lower ADC <subscript>skewness</subscript> (ADC values with the greatest frequency were higher) (p = 0.041), and higher PV (p = 0.022), NV (p < 0.01), T stage (p = 0.023), N stage (p < 0.01) and LRR (p < 0.01). On multivariate analysis the ADC <subscript>skewness</subscript> was no longer significant (p = 0.120) and only NV and LRR were independent predictors for DM+ (p = 0.023 and 0.021, respectively). DWI showed that compared to DM- patients, DM+ patients had a significantly lower primary tumour ADC <subscript>skewness</subscript> , but at initial presentation NV was the only independent predictor of DM.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma
Female
Humans
Male
Middle Aged
Nasopharyngeal Carcinoma
Neoplasm Metastasis
Predictive Value of Tests
Diffusion Magnetic Resonance Imaging methods
Nasopharyngeal Neoplasms diagnosis
Nasopharyngeal Neoplasms secondary
Nasopharynx diagnostic imaging
Neoplasm Staging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1434-4726
- Volume :
- 274
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 27722898
- Full Text :
- https://doi.org/10.1007/s00405-016-4333-6