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Evaluation of pharmacokinetics of single-dose chloroquine in malnourished children with malaria- a comparative study with normally nourished children.
- Source :
-
Indian journal of pharmacology [Indian J Pharmacol] 2016 Sep-Oct; Vol. 48 (5), pp. 498-502. - Publication Year :
- 2016
-
Abstract
- Objectives: Studies on antimalarial kinetics in children or adults who are undernourished or malnourished are both limited and have yielded conflicting results. The present study was carried out with the objectives of evaluating the pharmacokinetics of single dose chloroquine and its metabolite desethylchloroquine in children who were undernourished and compare them with children who were normally nourished.<br />Methods: Children of either gender between the ages of 5 and 12 years, smear positive for P. vivax malaria and classified either as well nourished or undernourished were included. Undernourishment was adjudged based on the Indian Academy of Pediatrics (IAP) classification of protein energy malnutrition [PEM] which in turn was based on Khadilkar's growth charts. All participants received 10 mg/kg on the first day followed by 10 mg/kg on Day 2 and 5 mg/kg on Day 3 along with supportive treatment. Blood samples for the levels of chloroquine [CQ] and desethylchloroquine [DECQ] were collected at 0, 0.5, 1, 2 4, 8, 12, 24, 48, 72 hours and 14 days after the first dose and levels assessed by High Performance Liquid Chromatography.<br />Results: A total of 12 children who were normally nourished and 13 who were undernourished were studied. Wide inter-individual variability was seen in the levels of both drug and metabolite in both groups of patients. However, the differences in Cmax, AUC 0-inf, Clearance, half life and Vd between the two groups were not significantly different.<br />Discussion: Our results indicate that dosage requirement is unlikely to be needed for chloroquine in undernourished children with uncomplicated P. vivax malaria.
- Subjects :
- Antimalarials administration & dosage
Antimalarials blood
Antimalarials therapeutic use
Child
Child Nutrition Disorders blood
Child Nutrition Disorders drug therapy
Child, Preschool
Chloroquine administration & dosage
Chloroquine analogs & derivatives
Chloroquine blood
Chloroquine therapeutic use
Female
Humans
Malaria, Vivax blood
Malaria, Vivax drug therapy
Male
Antimalarials pharmacokinetics
Child Nutrition Disorders metabolism
Chloroquine pharmacokinetics
Malaria, Vivax metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1998-3751
- Volume :
- 48
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Indian journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 27721533
- Full Text :
- https://doi.org/10.4103/0253-7613.190720