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The properties and utility of the CORE measure of melancholia.
- Source :
-
Journal of affective disorders [J Affect Disord] 2017 Jan 01; Vol. 207, pp. 128-135. Date of Electronic Publication: 2016 Sep 25. - Publication Year :
- 2017
-
Abstract
- Background: The CORE measure was designed to assess a central feature of melancholia - signs of psychomotor disturbance (PMD) - and so provide an alternate non-symptom based measure of melancholia or of its probability. This review evaluates development and application studies undertaken over the last 25 years to consider how well it has met its original objectives.<br />Methods: All studies published using the CORE measure as either the only or an adjunctive measure of melancholia were obtained and are considered in this review.<br />Results: Findings suggest high reliability in quantifying CORE scores can be achieved and that it has construct validity as a measure of PMD. A number of application studies assessing socio-demographic factors, cognitive and motor impairment, dexamethasone suppression and thyrotropin-releasing hormone, response to psychotherapy and to electroconvulsive therapy support its validity as a measure of melancholia, while functional brain imaging studies suggest that the measure identifies regions of decreased connectivity.<br />Limitations: Use of the CORE benefits from rater training and for subjects to be assessed at or near nadir of their depressive episode. There have been insufficient studies evaluating genetic factors, and the treatment response of CORE-defined melancholic patients to antidepressant drugs of differing classes.<br />Conclusions: The CORE, either as a proxy or direct measure of melancholia, provides a strategy for assigning depressed subjects a diagnosis or melancholic or non-melancholic depression or for estimating the probability of melancholia.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Antidepressive Agents therapeutic use
Brain physiopathology
Depressive Disorder diagnosis
Depressive Disorder psychology
Depressive Disorder therapy
Electroconvulsive Therapy
Humans
Psychiatric Status Rating Scales
Psychomotor Disorders diagnosis
Psychomotor Disorders psychology
Psychotherapy
Reproducibility of Results
Depressive Disorder physiopathology
Psychomotor Disorders physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2517
- Volume :
- 207
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 27721186
- Full Text :
- https://doi.org/10.1016/j.jad.2016.09.029