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[Clinical features and outcomes: analysis of 9 cases of HIV-negtive plasmablastic lymphoma].
- Source :
-
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2016 Sep 14; Vol. 37 (9), pp. 762-767. - Publication Year :
- 2016
-
Abstract
- Objective: To evaluate the clinical features and outcomes of HIV-negtive plasmablastic lymphoma (PBL). Methods: Nine patients with HIV-negtive PBL were diagnosed and treated between January 2006 and January 2016. The clinical and follow-up data were analyzed retrospectively. Results: The median age was 56 years (range 30-77 years) with a male-to-female ratio of 2∶1. Nobody had underlying diseases associated with immunosuppression. Primary extra nodal diseases were observed in 7 cases and only 1 patient had oral involvement. Two patients were in earlystage and 7 in advanced stage by the Ann Arbor stage system. Ki-67 index was 60%-90% in the 9 cases, and 80% or higher in 7 cases. Epstein-Barr virus-encoded RNA expression (EBER) was detected in 4 cases, and 2 of them were positive. Chemotherapy was documented in 9 patients, from which 8 received the cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP)-like regimens as the first-line chemotherapy and responses were observed in 5 (1 complete, 4 partial responses). Three elderly patients were treated with CHOP combined with thalidomide, and 2 of them achieved partial responses. One patient, failed three chemotherapy regimens, accepted thalidomide combined with etopside and achieved stable disease for 10 months. One patient with early stage had disease-free survival of 61.9 months after treatment. The other eight patients experienced recurrence or progression after the first-line chemotherapy, and 6 of them died of disease progression within 2 years after the diagnosis. Conclusion: The HIV-negative PBL patients in this study did not have an apparent association with immunosuppression. Primary extra nodal diseases were common, but only 1 patient had oral involvement. Most patients had advanced stage and poor prognosis. Effectiveness of thalidomide in the treatment of PBL deserves further investigation.
- Subjects :
- Adult
Aged
Cyclophosphamide administration & dosage
Disease-Free Survival
Doxorubicin administration & dosage
Female
HIV Infections
Herpesvirus 4, Human
Humans
Male
Middle Aged
Neoplasm Recurrence, Local
Prednisone administration & dosage
Remission Induction
Retrospective Studies
Thalidomide
Vincristine administration & dosage
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Plasmablastic Lymphoma drug therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-2727
- Volume :
- 37
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
- Publication Type :
- Academic Journal
- Accession number :
- 27719718
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0253-2727.2016.09.007