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[Correlation between the presence and intensity of symptoms and the results of hydrogen breath tests in the diagnosis of carbohydrate intolerance].
- Source :
-
Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru [Rev Gastroenterol Peru] 2016 Jul-Sep; Vol. 36 (3), pp. 225-230. - Publication Year :
- 2016
-
Abstract
- Background: Hydrogen breath tests (HBT) are used to confirm the diagnosis of carbohydrate intolerance or small intestinal bacterial overgrowth (SIBO).<br />Objective: Determine the existence of a correlation between the presence and intensity of symptoms experimented by the patient after the ingestion of a carbohydrate load and the test result.<br />Materials and Methods: This is an observational, retrospective and analytic study, in which all patients' files from year 2008 to 2014 containing a report of a HBT performed at Hospital San José TEC de Monterrey were revised. Using a visual analogue scale (VAS), the patient reported the intensity of gastrointestinal symptoms during the test. Descriptive statistics were obtained, and exclusively for lactose HBTs, Pearson's correlation coefficient (r) between maximum hydrogen concentration in breath and symptom intensity was calculated.<br />Results: A HBT was performed in 33 patients: 23 with lactose, 5 with fructose, and 5 with lactulose as substrate. Of these, 10, 2, and 5 tests were positive, respectively. For lactose HBTs, the symptom with most sensitivity was flatulence (80%), which also had the greatest likelihood ratio for a positive test (1.73). Diarrhea had the greatest specificity (84.6%). A tendency for positivity was observed when patients presented symptoms. A moderately positive correlation between hydrogen ppm and symptom intensity was found (r=0.427, p=0.023).<br />Conclusions: A correlation between symptom intensity and test positivity was found in patients with lactose intolerance. The presence of flatulence after lactose loading may be indicative of a positive test.
- Subjects :
- Adolescent
Adult
Aged
Biomarkers metabolism
Breath Tests
Child
Child, Preschool
Female
Flatulence etiology
Fructose Intolerance metabolism
Humans
Infant
Lactose Intolerance metabolism
Male
Middle Aged
Retrospective Studies
Sensitivity and Specificity
Young Adult
Fructose Intolerance diagnosis
Hydrogen metabolism
Lactose Intolerance diagnosis
Subjects
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1609-722X
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru
- Publication Type :
- Academic Journal
- Accession number :
- 27716759