Caging the uncageable: using metal complex release for photochemical control over irreversible inhibition.

Authors :: Huisman M
White JK
Lewalski VG
Podgorski I
Turro C
Kodanko JJ
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2016 Oct 18; Vol. 52 (85), pp. 12590-12593.
Publication Year :: 2016
Abstract: Photochemical control over irreversible inhibition was shown using Ru(ii)-caged inhibitors of cathepsin L. Levels of control were dependent on where the Ru(ii) complex was attached to the organic inhibitor, reaching >10 : 1 with optimal placement. A new strategy for photoreleasing Ru(ii) fragments from inhibitor-enzyme conjugates is also reported.

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