Familial Brain Periventricular Pseudocysts.

Authors :: Shinar S
Malinger G
Leibovitz Z
Ben-Sira L
Leshinsky-Silver E
Gindes L
Lerman-Sagie T
Kidron D
Lev D
Source :: Fetal diagnosis and therapy [Fetal Diagn Ther] 2017; Vol. 42 (1), pp. 42-47. Date of Electronic Publication: 2016 Oct 07.
Publication Year :: 2017
Abstract: Introduction: We report the rare finding of recurrent periventricular pseudocysts (PVPC) in consecutive pregnancies in 4 families and their postnatal outcome.<br />Materials and Methods: We reviewed the databases of 3 large ultrasound units searching for the diagnosis of PVPC in 2 pregnancies of the same patient.<br />Results: The first case of recurrent PVPC was diagnosed in 2011 and since then 3 additional families were diagnosed (8 cases of PVPC all in all). All fetuses underwent fetal MRI that confirmed the presence of frontal or frontocaudal PVPC. Amniocentesis, when performed, demonstrated a normal karyotype. Termination of pregnancy was carried out in 2 pregnancies in 2 of 4 families. The remaining 6 pregnancies ended with a term delivery, and to date all babies are developing normally.<br />Conclusion: The rare finding of recurrent brain PVPC in consecutive pregnancies raises the possibility of a hereditary etiology as opposed to a sporadic event. As in isolated PVPC, frontocaudal 'familial PVPC' appears to carry a favorable prognosis.<br /> (© 2016 S. Karger AG, Basel.)