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Molecular basis of human cerebral malaria development.
- Source :
-
Tropical medicine and health [Trop Med Health] 2016 Sep 27; Vol. 44, pp. 33. Date of Electronic Publication: 2016 Sep 27 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Cerebral malaria is still a deleterious health problem in tropical countries. The wide spread of malarial drug resistance and the lack of an effective vaccine are obstacles for disease management and prevention. Parasite and human genetic factors play important roles in malaria susceptibility and disease severity. The malaria parasite exerted a potent selective signature on the human genome, which is apparent in the genetic polymorphism landscape of genes related to pathogenesis. Currently, much genomic data and a novel body of knowledge, including the identification of microRNAs, are being increasingly accumulated for the development of laboratory testing cassettes for cerebral malaria prevention. Therefore, understanding of the underlying complex molecular basis of cerebral malaria is important for the design of strategy for cerebral malaria treatment and control.
Details
- Language :
- English
- ISSN :
- 1348-8945
- Volume :
- 44
- Database :
- MEDLINE
- Journal :
- Tropical medicine and health
- Publication Type :
- Academic Journal
- Accession number :
- 27708543
- Full Text :
- https://doi.org/10.1186/s41182-016-0033-6