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PMEPA1, a TGF-β- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2016 Oct 28; Vol. 479 (4), pp. 615-621. Date of Electronic Publication: 2016 Oct 01. - Publication Year :
- 2016
-
Abstract
- Prostate transmembrane protein, androgen induced 1 (PMEPA1) is highly expressed in various solid tumors and is known to play important roles in the transforming growth factor-β (TGF-β) signaling pathway. Here, we demonstrate a novel relationship between PMEPA1 and hypoxia, a common microenvironmental stress condition in solid tumors. We showed that induction of PMEPA1 expression occurred during hypoxia in a manner dependent on both TGF-β signaling and hypoxia-inducible factor-1 (HIF-1) pathways. Furthermore, overexpression and knockdown experiments revealed that PMEPA1 enhanced HIF-1 transcription activity. Bioinformatics analyses of PMEPA1-correlated genes using a gene expression database in clinical settings showed significant enrichment of gene sets defined by TGF-β and hypoxia and these two signaling pathways-related angiogenesis and epithelial-mesenchymal transition in many types of solid tumors. Collectively, our findings indicated that PMEPA1 participates in TGF-β- and hypoxia-regulated gene expression networks in solid tumors and thereby may contribute to tumor progression.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Cell Line, Tumor
Gene Knockdown Techniques
Gene Regulatory Networks
Humans
Intracellular Signaling Peptides and Proteins
Membrane Proteins genetics
Mitochondrial Proteins
Neoplasm Proteins genetics
Transcription, Genetic
Transforming Growth Factor beta genetics
Gene Expression Regulation, Neoplastic
Membrane Proteins metabolism
Neoplasm Proteins metabolism
Neoplasms genetics
Neoplasms pathology
Transforming Growth Factor beta metabolism
Tumor Hypoxia genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 479
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 27697531
- Full Text :
- https://doi.org/10.1016/j.bbrc.2016.09.166