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Accelerated growth after recombinant human growth hormone treatment of children with chronic renal failure.
- Source :
-
The Journal of pediatrics [J Pediatr] 1989 Sep; Vol. 115 (3), pp. 365-71. - Publication Year :
- 1989
-
Abstract
- We studied the effect of recombinant human growth hormone treatment on five boys, aged 4.6 +/- 1.8 years, who had chronic renal failure secondary to congenital renal diseases (mean creatinine clearance (+/- SD): 18.3 +/- 6.3 ml/min/1.73 m2 (0.32 +/- 0.11 ml/sec/1.73 m2]. Patients received 0.125 mg/kg of growth hormone three times per week for 1 year. Before beginning treatment, the children had a mean annual growth velocity of 4.9 +/- 1.4 cm/yr (range 3.0 to 6.3 cm/yr), with a mean standard deviation score for a height of -2.98 +/- 0.73 (range -2.16 to -3.59). At the end of therapy, the mean growth velocity had increased to 8.9 +/- 1.2 cm/yr (range 7.5 to 10.7 cm/yr), and the mean height standard deviation score improved to -2.36 +/- 0.83 (range -1.15 to -3.18). Bone age advancement was consistent with the period of growth. Routine laboratory determinations, including results of glucose tolerance testing, did not vary significantly from pretreatment levels. These preliminary data indicate that growth-retarded children with chronic renal failure can respond to exogenous growth hormone therapy with a marked acceleration in growth velocity.
- Subjects :
- Age Determination by Skeleton
Anthropometry
Blood Glucose metabolism
Calcium blood
Child
Child, Preschool
Follow-Up Studies
Growth Hormone blood
Humans
Kidney physiopathology
Kidney Diseases complications
Kidney Diseases congenital
Kidney Failure, Chronic etiology
Kidney Failure, Chronic metabolism
Male
Phosphorus blood
Recombinant Proteins
Thyroid Function Tests
Child Development drug effects
Growth Hormone therapeutic use
Kidney Failure, Chronic therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 115
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 2769495
- Full Text :
- https://doi.org/10.1016/s0022-3476(89)80833-9