Hemoptysis in a Patient with Elevated Immunoglobulin E.

Authors :: Gernez Y
Tsuang A
Smith TD
Shahjehan K
Hui Y
Maglione PJ
Cunningham-Rundles C
Source :: The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2016 Nov - Dec; Vol. 4 (6), pp. 1054-1058. Date of Electronic Publication: 2016 Sep 29.
Publication Year :: 2016
Abstract: Recurrent pneumonia with cavitation leading to pneumatoceles, secondary fungal infections, and hemoptysis are major causes of mortality and morbidity in patients with hyper-IgE syndrome. Prevention and aggressive treatment of pneumonia in these patients are essential to prevent further lung damage, but treatment may be delayed because the classic signs/symptoms of infection such as fever, chills, or rigors may be lacking. Early imaging to identify infection is essential for diagnosis and treatment. The mainstay of therapy is continuous, full-dose daily trimethoprim-sulfamethoxazole and commonly fungal coverage. Because hyper-IgE syndrome is a progressive disease, patients' condition may worsen despite compliance with prophylactic therapy.<br /> (Copyright © 2016 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)