Effects of GABA on the expression of type I collagen gene in normal human dermal fibroblasts.

Authors :: Uehara E
Hokazono H
Sasaki T
Yoshioka H
Matsuo N
Source :: Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2017 Feb; Vol. 81 (2), pp. 376-379. Date of Electronic Publication: 2016 Oct 03.
Publication Year :: 2017
Abstract: We examined the effects of GABA on type I collagen gene expression in normal human dermal fibroblasts. Real-time PCR analysis indicated GABA increased the level of type I collagen transcripts, and suppressed the expression of matrix metalloproteinase-1, which is a collagen-degrading enzyme. These results suggest GABA improves the skin elasticity by regulating type I collagen expression.

Subjects :: Collagen Type I, alpha 1 Chain
Humans
Matrix Metalloproteinase 1 genetics
RNA, Messenger genetics
RNA, Messenger metabolism
Collagen Type I genetics
Fibroblasts drug effects
Fibroblasts metabolism
Gene Expression Regulation drug effects
Skin cytology
gamma-Aminobutyric Acid pharmacology

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