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Control of non-apoptotic nurse cell death by engulfment genes in Drosophila.
- Source :
-
Fly [Fly (Austin)] 2017 Apr 03; Vol. 11 (2), pp. 104-111. Date of Electronic Publication: 2016 Sep 29. - Publication Year :
- 2017
-
Abstract
- Programmed cell death occurs as a normal part of oocyte development in Drosophila. For each egg that is formed, 15 germline-derived nurse cells transfer their cytoplasmic contents into the oocyte and die. Disruption of apoptosis or autophagy only partially inhibits the death of the nurse cells, indicating that other mechanisms significantly contribute to nurse cell death. Recently, we demonstrated that the surrounding stretch follicle cells non-autonomously promote nurse cell death during late oogenesis and that phagocytosis genes including draper, ced-12, and the JNK pathway are crucial for this process. When phagocytosis genes are inhibited in the follicle cells, events specifically associated with death of the nurse cells are impaired. Death of the nurse cells is not completely blocked in draper mutants, suggesting that other engulfment receptors are involved. Indeed, we found that the integrin subunit, αPS3, is enriched on stretch follicle cells during late oogenesis and is required for elimination of the nurse cells. Moreover, double mutant analysis revealed that integrins act in parallel to draper. Death of nurse cells in the Drosophila ovary is a unique example of programmed cell death that is both non-apoptotic and non-cell autonomously controlled.
- Subjects :
- Animals
Drosophila Proteins metabolism
Drosophila melanogaster genetics
Drosophila melanogaster growth & development
Drosophila melanogaster metabolism
Female
Integrin alpha Chains metabolism
Integrins metabolism
Membrane Proteins metabolism
Ovary cytology
Ovum metabolism
Cell Death
Drosophila melanogaster cytology
Ovarian Follicle cytology
Subjects
Details
- Language :
- English
- ISSN :
- 1933-6942
- Volume :
- 11
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Fly
- Publication Type :
- Academic Journal
- Accession number :
- 27686122
- Full Text :
- https://doi.org/10.1080/19336934.2016.1238993