Back to Search
Start Over
A case report of pancreatic metastasis from synovial sarcoma successfully treated by metastasectomy with adjuvant chemotherapy.
- Source :
-
Medicine [Medicine (Baltimore)] 2016 Sep; Vol. 95 (39), pp. e4789. - Publication Year :
- 2016
-
Abstract
- Introduction: Synovial sarcoma is a malignant soft tissue sarcoma which arises near joints. The most frequent metastasis sites of synovial sarcoma are the lungs, lymph nodes, and bone. Pancreatic metastasis is quite rare; only 3 cases have been reported worldwide to date. We herein present the 4th case of pancreatic metastasis from synovial sarcoma.<br />Methods and Results: A 32-year-old man underwent extended excision of synovial sarcoma in the left pelvis and femur in 2009. In 2013, follow-up contrast-enhanced computed tomography revealed a 35-mm heterogeneously enhanced mass in the pancreas body. Endoscopic ultrasound-guided fine needle aspiration of the mass revealed a diffuse proliferation of atypical spindle cells in a fascicular arrangement. Because the histology was quite similar to the resected specimen of synovial sarcoma in 2009, the mass was suspected to be a metastasis from synovial sarcoma. Laparoscopic distal pancreatectomy with adjuvant adriamycin/ifosfamide chemotherapy was subsequently performed. Synovial sarcoma-specific SS18-SSX1 (synovial sarcoma translocation, chromosome 18-synovial sarcoma X1) or SS18-SSX2 chimera mRNA was detected in the resected specimen, confirming the diagnosis of metastasis from synovial sarcoma. The patient did well for 30 months without recurrence.<br />Conclusion: This case suggests that pancreatic metastasis from synovial sarcoma can be successfully treated by metastasectomy with adjuvant chemotherapy.<br />Competing Interests: The authors report no conflicts of interest.
- Subjects :
- Adult
Chemotherapy, Adjuvant
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Humans
Male
Pancreatic Neoplasms drug therapy
Pancreatic Neoplasms surgery
Bone Neoplasms pathology
Metastasectomy methods
Pancreatic Neoplasms secondary
Pancreatic Neoplasms therapy
Sarcoma, Synovial pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 95
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27684804
- Full Text :
- https://doi.org/10.1097/MD.0000000000004789