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Population-Based External Validation of the Updated 2012 Partin Tables in Contemporary North American Prostate Cancer Patients.
- Source :
-
The Prostate [Prostate] 2017 Jan; Vol. 77 (1), pp. 105-113. Date of Electronic Publication: 2016 Sep 29. - Publication Year :
- 2017
-
Abstract
- Objective: To externally validate the updated 2012 Partin Tables in contemporary North American patients treated with radical prostatectomy (RP) for localized prostate cancer (PCa) at community institutions.<br />Materials and Methods: We examined records of 25,254 patients treated with RP and pelvic lymph node dissection (PLND) between 2010 and 2013, within the surveillance, epidemiology, and end results database. The ROC derived AUC assessed discriminant properties of the updated 2012 Partin Tables of organ confined disease (OC), extracapsular extension (ECE), seminal vesical invasion (SVI), and lymph node invasion (LNI). Calibration plots focused on calibration between predicted and observed rates.<br />Results: Proportions of OC, ECE, SVI, and LNI at RP were 69.8%, 18.4%, 7.4%, and 4.4%, respectively. Accuracy for prediction of OC, ECE, SVI, and LNI was 70.4%, 59.9%, 72.9%, and 77.1%, respectively. In subgroup analyses in patients with nodal yield >10, accuracy for LNI prediction was 76.0%. Subgroup analyses in elderly patients and in African American patients revealed decreased accuracy for prediction of all four endpoints. Last but not least, SVI and LNI calibration plots showed excellent agreement, versus good agreement for OC (maximum underestimation of 10%) and poor agreement for ECE (maximum overestimation of 12%).<br />Conclusion: Taken together, the updated 2012 Partin Tables can be unequivocally endorsed for prediction of OC, SVI, and LNI in community-based patients with localized PCa. Conversely, ECE predictions failed to reach the minimum accuracy requirements of 70%. Prostate 77:105-113, 2017. © 2016 Wiley Periodicals, Inc.<br /> (© 2016 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Humans
Lymph Node Excision trends
Male
Middle Aged
North America epidemiology
Prostatectomy trends
Prostatic Neoplasms diagnosis
United States epidemiology
Nomograms
Population Surveillance methods
Prostatic Neoplasms epidemiology
Prostatic Neoplasms surgery
SEER Program standards
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0045
- Volume :
- 77
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Prostate
- Publication Type :
- Academic Journal
- Accession number :
- 27683103
- Full Text :
- https://doi.org/10.1002/pros.23253