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[Application study on regional infusion chemotherapy by celiac trunk during operation in advanced gastric cancer patients].
- Source :
-
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery [Zhonghua Wei Chang Wai Ke Za Zhi] 2016 Sep 25; Vol. 19 (9), pp. 1044-1048. - Publication Year :
- 2016
-
Abstract
- Objective: To explore the feasibility, safety and efficacy of intraoperative regional infusion chemotherapy by celiac trunk in advanced gastric cancer patients.<br />Methods: One hundred and twenty-six patients with advanced gastric cancer(stageII(-III() were screened from database of Gastrointestinal Surgery Department of Taizhou People's Hospital between January 2008 and December 2010 who underwent R0 resection and D2 lymphadenectomy, received postoperative chemotherapy(XELOX or FOLFOX), and had complete follow-up data. They were divided into infusion chemotherapy group (65 cases) and control group (61 cases) according to regional infusion chemotherapy or not (fluorine 1 000 mg and cisplatin 60 mg). The side effects of chemotherapy, parameters related to the operation, long-term survival and relapse rate were compared between the two groups.<br />Results: The baseline data between the two groups were comparable(all P>0.05). Postoperative III( and IIII( adverse reaction of chemotherapy was not significantly different between the two groups (P>0.05). The time of postoperative intestinal function recovery [(67.9±14.8) hours vs. (68.9±15.0) hours, t=-0.380, P=0.705), volume of postoperative 1-week drainage [(66.1±17.1) ml vs.(61.9±18.2) ml, t=1.478, P=0.142], recent morbidity of complications[55.4%(36/65) vs. 49.2%(30/61), χ <superscript>2</superscript> =0.256, P=0.613], and the long-term morbidity of complications [16.9% (11/65) vs. 14.8% (9/61), χ <superscript>2</superscript> =0.111, P=0.739] were all not significantly different between the two groups. The 3-year survival rate and 3-year relapse-free survival rate in infusion chemotherapy group were significantly higher than those in control group(58.4% vs. 37.7%, χ <superscript>2</superscript> =5.382, P=0.020; 58.4% vs. 34.4%, χ <superscript>2</superscript> =6.636, P=0.010).<br />Conclusion: Regional infusion chemotherapy by celiac trunk during operation for advanced gastric cancer patients is safe and feasible, and can reduce the risk of local recurrence and improve survival rate.
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
Capecitabine
Celiac Artery
Chemotherapy, Cancer, Regional Perfusion adverse effects
Cisplatin adverse effects
Deoxycytidine analogs & derivatives
Deoxycytidine therapeutic use
Disease-Free Survival
Fluorine adverse effects
Fluorouracil analogs & derivatives
Fluorouracil therapeutic use
Gastrectomy
Humans
Leucovorin therapeutic use
Lymph Node Excision
Organoplatinum Compounds therapeutic use
Oxaliplatin
Oxaloacetates
Postoperative Complications
Recovery of Function
Survival Rate
Chemotherapy, Cancer, Regional Perfusion methods
Chemotherapy, Cancer, Regional Perfusion mortality
Cisplatin administration & dosage
Cisplatin therapeutic use
Fluorine administration & dosage
Fluorine therapeutic use
Neoplasm Recurrence, Local prevention & control
Stomach Neoplasms drug therapy
Stomach Neoplasms mortality
Stomach Neoplasms surgery
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1671-0274
- Volume :
- 19
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
- Publication Type :
- Academic Journal
- Accession number :
- 27680076