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Regulation of eosinophil development and survival.
- Source :
-
Current opinion in hematology [Curr Opin Hematol] 2017 Jan; Vol. 24 (1), pp. 9-15. - Publication Year :
- 2017
-
Abstract
- Purpose of Review: Eosinophils are a subset of granulocytes generally associated with type 2 immune responses. They can contribute to protection against helminths but also mediate pro-inflammatory functions during allergic immune responses. Only recently, eosinophils were also found to exert many other functions such as regulation of glucose and fat metabolism, thermogenesis, survival of plasma cells, and antitumor activity. The mechanisms that control eosinophil development and survival are only partially understood.<br />Recent Findings: Here we review new findings regarding the role of cell-extrinsic and cell-intrinsic factors for eosinophilopoiesis and eosinophil homeostasis. Several reports provide new insights in the regulation of eosinophil development by transcription factors, miRNAs and epigenetic modifications. Danger signals like lipopolysaccharide or alarmins can activate eosinophils but also prolong their lifespan. We further reflect on the observations that eosinophil development is tightly controlled by the unfolded protein stress response and formation of cytoplasmic granules.<br />Summary: Eosinophils emerge as important regulators of diverse biological processes. Their differentiation and survival is tightly regulated by factors that are still poorly understood. Newly identified pathways involved in eosinophilopoiesis and eosinophil homeostasis may lead to development of new therapeutic options for treatment of eosinophil-associated diseases.
- Subjects :
- Alarmins genetics
Alarmins metabolism
Animals
Antigens, Differentiation, Myelomonocytic genetics
Antigens, Differentiation, Myelomonocytic metabolism
Bone Marrow
Cell Survival
Eosinophils pathology
Gene Expression Regulation
Granulocyte Precursor Cells cytology
Granulocyte Precursor Cells physiology
Homeostasis
Humans
Interleukin-5 metabolism
MicroRNAs genetics
Protein Binding
Signal Transduction
Transcription Factors metabolism
Cell Differentiation
Eosinophils cytology
Eosinophils physiology
Leukopoiesis
Subjects
Details
- Language :
- English
- ISSN :
- 1531-7048
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current opinion in hematology
- Publication Type :
- Academic Journal
- Accession number :
- 27673511
- Full Text :
- https://doi.org/10.1097/MOH.0000000000000293