Back to Search
Start Over
Transgenerational disruption of functional 5-HT 1A R-induced connectivity in the adult mouse brain by traumatic stress in early life.
- Source :
-
Molecular psychiatry [Mol Psychiatry] 2017 Apr; Vol. 22 (4), pp. 519-526. Date of Electronic Publication: 2016 Sep 27. - Publication Year :
- 2017
-
Abstract
- Traumatic stress in early life is a strong risk factor for psychiatric disorders that can affect individuals across several generations. Although the underlying mechanisms have been proposed to implicate serotonergic transmission in the brain, the neural circuits involved remain poorly delineated. Using pharmacological functional magnetic resonance imaging in mice, we demonstrate that traumatic stress in postnatal life alters 5-HT <subscript>1A</subscript> receptor-evoked local and global functions in both, the exposed animals and their progeny when adult. Disrupted functional connectivity is consistent across generations and match limbic circuits implicated in mood disorders, but also networks not previously linked to traumatic stress. These findings underscore the neurobiology and functional mapping of transgenerational effects of early life experiences.
- Subjects :
- Adult
Animals
Brain metabolism
Brain Mapping methods
Connectome methods
Family Characteristics
Humans
Mental Disorders physiopathology
Mice
Neural Pathways physiopathology
Neurobiology methods
Stress, Psychological physiopathology
Receptor, Serotonin, 5-HT1A metabolism
Stress, Psychological metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5578
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 27671475
- Full Text :
- https://doi.org/10.1038/mp.2016.146