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HMDSO-plasma coated electrospun fibers of poly(cyclodextrin)s for antifungal dressings.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2016 Nov 20; Vol. 513 (1-2), pp. 518-527. Date of Electronic Publication: 2016 Sep 22. - Publication Year :
- 2016
-
Abstract
- Electrospun mats containing cyclodextrin polymers (poly-αCD or poly-βCD) were developed to act as wound dressings showing tunable release rate of the antifungal agent fluconazole incorporated forming inclusion complexes. Poly-αCD and poly-βCD were prepared via cross-linking with epichlorohydrin (EPI) as water-soluble large molecular weight polymers. Then, polyCDs forming complexes with fluconazole were mixed with poly-(ε-caprolactone) (PCL) or poly(N-vinylpyrrolidone) (PVP) for electrospinning. Obtained bead-free fibers showed a random distribution, diameters in the 350-850nm range, and a variety of physical stability behaviors in aqueous environment. Mats were coated by hexamethyldisiloxane (HMDSO) plasma polymerization to create a hydrophobic layer that prevented rapid drug diffusion. HMDSO coating was evidenced by the Si content of mat surface (EDX analysis) and by the increase in the water contact angle (up to 130°). In physiological-mimicking medium, non-treated mats showed burst release of fluconazole, whereas HMDSO-coated mats sustained the release and delayed disintegration of PVP-based mats. Antifungal tests evidenced that both coated and non-coated mats efficiently inhibited the growth of Candida albicans.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Antifungal Agents administration & dosage
Candida albicans drug effects
Candida albicans growth & development
Cellulose administration & dosage
Cyclodextrins administration & dosage
Drug Carriers administration & dosage
Drug Liberation
Fluconazole administration & dosage
Hydrophobic and Hydrophilic Interactions
Pyrrolidinones administration & dosage
Pyrrolidinones chemistry
Siloxanes administration & dosage
Technology, Pharmaceutical
Antifungal Agents chemistry
Bandages
Cellulose chemistry
Cyclodextrins chemistry
Drug Carriers chemistry
Fluconazole chemistry
Siloxanes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 513
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 27667755
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2016.09.064