Ru(II) complexes bearing guanidinium ligands as potent anticancer agents.

Authors :: Chen WX
Song XD
He SF
Sun J
Chen JX
Wu T
Mao ZW
Source :: Journal of inorganic biochemistry [J Inorg Biochem] 2016 Nov; Vol. 164, pp. 91-98. Date of Electronic Publication: 2016 Sep 14.
Publication Year :: 2016
Abstract: Two ruthenium(II) complexes containing guanidinium ligands have been synthesized and characterized for the first time. It was found that the two complexes exhibit moderate antitumor activity in Hela, A549, CNE-2, MCF-7, and HepG2 human tumor cells. Flow cytometric analysis showed that both complexes arrested the cell cycle in the G2/M phase and induced apoptosis in Hela cells. Mechanism studies indicate that both complexes induced apoptosis through caspase- and reactive oxygen species (ROS)-dependent pathways. Additionally, the two complexes displayed higher phototoxicity to tumor cells and almost no influence on normal liver LO2 cells upon irradiation at 450nm.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)