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Predictors of sentinel lymph node metastases in breast cancer-radioactivity and Ki-67.
- Source :
-
Breast (Edinburgh, Scotland) [Breast] 2016 Dec; Vol. 30, pp. 87-91. Date of Electronic Publication: 2016 Sep 23. - Publication Year :
- 2016
-
Abstract
- Objectives: Since the introduction of the sentinel node technique for breast cancer in the 1990s patient's morbidity was reduced. Tracer uptake is known to be dependent from lymph node integrity and activity of macrophages. The aim of this study was to assess whether radioactivity of the tracer can predict sentinel lymph node metastases. Furthermore, a potential association with Ki-67 index was examined. Non-invasive prediction of lymph node metastases could lead to a further decrease of morbidity.<br />Methods: We retrospectively analyzed patients with primary breast cancer who underwent surgery at the Department of Obstetrics and Gynecology in the University Hospital of Cologne between 2012 and 2013. Injection of radioactive tracer was done a day before surgery in the department of Nuclear Medicine. Clinical data and radioactivity of the sentinel node measured the day before and intraoperatively were abstracted from patient's files.<br />Results: Of 246 patients, 64 patients had at least one, five patients had two and one patient had three positive sentinel lymph nodes. Occurrence of sentinel lymph node metastases was not associated with preoperative tracer activity (p = 0,319), intraoperative tracer activity of first sentinel node (p = 0,086) or with loss of tracer activity until operation (p = 0,909). There was no correlation between preoperative Ki-67 index and occurrence of lymph node metastases (p = 0,403).<br />Conclusion: In our cohort, there was no correlation between radioactivity and sentinel node metastases. Tracer uptake might not only be influenced by lymph node metastases and does not predict metastatic lymph node involvement.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Breast Neoplasms pathology
Breast Neoplasms surgery
Female
Humans
Logistic Models
Lymphatic Metastasis
Mastectomy
Mastectomy, Segmental
Middle Aged
Neoplasm Staging
Radioactive Tracers
Radioactivity
Retrospective Studies
Sentinel Lymph Node Biopsy
Breast Neoplasms metabolism
Ki-67 Antigen metabolism
Radiopharmaceuticals metabolism
Sentinel Lymph Node pathology
Technetium Tc 99m Aggregated Albumin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3080
- Volume :
- 30
- Database :
- MEDLINE
- Journal :
- Breast (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 27665485
- Full Text :
- https://doi.org/10.1016/j.breast.2016.09.003