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Is there any difference in Amide and NOE CEST effects between white and gray matter at 7T?
- Source :
-
Journal of magnetic resonance (San Diego, Calif. : 1997) [J Magn Reson] 2016 Nov; Vol. 272, pp. 82-86. Date of Electronic Publication: 2016 Sep 16. - Publication Year :
- 2016
-
Abstract
- Measurement of Chemical Exchange Saturation Transfer (CEST) is providing tissue physiology dependent contrast, e.g. by looking at Amide and NOE (Nuclear Overhauser Enhancement) effects. CEST is unique in providing quantitative metabolite information at high imaging resolution. However, direct comparison of Amide and NOE effects between different tissues may result in wrong conclusions on the metabolite concentration due to the additional contributors to the observed CEST contrast, such as water content (WC) and water T <subscript>1</subscript> relaxation (T <subscript>1w</subscript> ). For instance, there are multiple contradictory reports in the literature on Amide and NOE effects in white matter (WM) and gray matter (GM) at 7T. This study shows that at 7T, tissue water T <subscript>1</subscript> relaxation is a stronger contributor to CEST contrasts than WC. After water T <subscript>1</subscript> correction, there was no difference in Amide effects between WM and GM, whereas WM/GM contrast was enhanced for NOE effects.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1096-0856
- Volume :
- 272
- Database :
- MEDLINE
- Journal :
- Journal of magnetic resonance (San Diego, Calif. : 1997)
- Publication Type :
- Academic Journal
- Accession number :
- 27662404
- Full Text :
- https://doi.org/10.1016/j.jmr.2016.09.010