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Pd-Catalyzed Carboamination of Alkylidenecyclopropanes: Synthesis of Congested Pyrrolidines and Piperidines.

Authors :
Lazzara PR
Fitzpatrick KP
Eichman CC
Source :
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2016 Nov 14; Vol. 22 (47), pp. 16779-16782. Date of Electronic Publication: 2016 Oct 11.
Publication Year :
2016

Abstract

The synthesis of densely functionalized N-heterocycles is an ongoing challenge in chemical synthesis. Herein, we report an efficient method for the construction of pyrrolidine and piperidine scaffolds using a palladium-catalyzed carboamination of alkylidenecyclopropanes.<br /> (© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1521-3765
Volume :
22
Issue :
47
Database :
MEDLINE
Journal :
Chemistry (Weinheim an der Bergstrasse, Germany)
Publication Type :
Academic Journal
Accession number :
27661456
Full Text :
https://doi.org/10.1002/chem.201604077