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Cognitive decline following incident and preexisting diabetes mellitus in a population sample.
- Source :
-
Neurology [Neurology] 2016 Oct 18; Vol. 87 (16), pp. 1681-1687. Date of Electronic Publication: 2016 Sep 21. - Publication Year :
- 2016
-
Abstract
- Objective: To examine if incident and preexisting diabetes mellitus (DM) were associated with cognitive decline among African Americans (AAs) and European Americans (EAs).<br />Methods: Based on a prospective study of 7,740 older adults (mean age 72.3 years, 64% AA, 63% female), DM was ascertained by hypoglycemic medication use and Medicare claims during physician or hospital visits, and cognition by performance on a brief battery for executive functioning, episodic memory, and Mini-Mental State Examination (MMSE). Decline in composite and individual tests among those with incident DM, with preexisting DM, and without DM was studied using a linear mixed effects model with and without change point.<br />Results: At baseline, 737 (15%) AAs and 269 (10%) EAs had preexisting DM. Another 721 (17%) AAs and 289 (12%) EAs had incident DM in old age. Following incident DM, cognitive decline increased by 36% among AAs and by 40% among EAs compared to those without DM. No significant difference was observed between AAs and EAs (p = 0.64). However, cognitive decline increased by 17% among AAs with preexisting DM compared to those without DM, but no increased decline was observed among EAs with preexisting DM. In secondary analyses, faster decline in executive functioning and episodic memory was observed following incident DM.<br />Conclusions: In old age, faster cognitive decline was present among AAs and EAs following incident DM, compared to cognitive decline prior to DM, and among those without DM. This underscores the need for stronger prevention and control of DM in old age.<br /> (© 2016 American Academy of Neurology.)
- Subjects :
- Black or African American
Aged
Chicago
Cognition
Diabetes Mellitus, Type 2 complications
Disease Progression
Female
Follow-Up Studies
Humans
Hypoglycemic Agents therapeutic use
Incidence
Linear Models
Longitudinal Studies
Male
Mental Status Schedule
Prospective Studies
Time Factors
White People
Cognitive Dysfunction complications
Cognitive Dysfunction ethnology
Diabetes Complications ethnology
Diabetes Complications psychology
Diabetes Mellitus, Type 2 ethnology
Diabetes Mellitus, Type 2 psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 87
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 27655734
- Full Text :
- https://doi.org/10.1212/WNL.0000000000003226