Back to Search
Start Over
Retrospective analysis of oncogenic human papilloma virus and Epstein-Barr virus prevalence in Turkish nasopharyngeal cancer patients.
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2016 Nov; Vol. 212 (11), pp. 1021-1026. Date of Electronic Publication: 2016 Sep 03. - Publication Year :
- 2016
-
Abstract
- Nasopharyngeal carcinoma (NPC) is associated with the Epstein-Barr virus (EBV). Human papilloma virus (HPV) has also been detected in NPC cases. In this retrospective study, we analyze the frequency of EBV and HPV infection in 82 Turkish patients with NPC. A total of 82 were evaluated for EBV and HPV. In situ hybridization (ISH) was performed for EBV. HPV-ISH and P16 immunohistochemistry used to determine the HPV status. Seventy-two of the 82 (87%) NPC patients were EBV-positive. The highest rate of EBV-positivity was found in undifferentiated NPC patients, which accounted for 65 of 68 (95.6%) undifferentiated cases. One of the 82 NPC patients whose tumor was non-keratinizing differentiated, contained HPV. Our data shows that EBV is closely associated with NPC in Turkey. We found lower rates of HPV-positivity in NPC patients than in North American populations. In addition, both EBV and HPV-negativity were more associated with decreased survival than EBV-positive cases.<br /> (Copyright © 2016 Elsevier GmbH. All rights reserved.)
- Subjects :
- Adult
Aged
Carcinoma
Female
Humans
Immunohistochemistry
In Situ Hybridization
Kaplan-Meier Estimate
Male
Middle Aged
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms mortality
Prevalence
Retrospective Studies
Turkey
Young Adult
Epstein-Barr Virus Infections epidemiology
Nasopharyngeal Neoplasms virology
Papillomavirus Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 212
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 27640103
- Full Text :
- https://doi.org/10.1016/j.prp.2016.08.013