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West African Anopheles gambiae mosquitoes harbor a taxonomically diverse virome including new insect-specific flaviviruses, mononegaviruses, and totiviruses.
- Source :
-
Virology [Virology] 2016 Nov; Vol. 498, pp. 288-299. Date of Electronic Publication: 2016 Sep 15. - Publication Year :
- 2016
-
Abstract
- Anopheles gambiae are a major vector of malaria in sub-Saharan Africa. Viruses that naturally infect these mosquitoes may impact their physiology and ability to transmit pathogens. We therefore used metagenomics sequencing to search for viruses in adult Anopheles mosquitoes collected from Liberia, Senegal, and Burkina Faso. We identified a number of virus and virus-like sequences from mosquito midgut contents, including 14 coding-complete genome segments and 26 partial sequences. The coding-complete sequences define new viruses in the order Mononegavirales, and the families Flaviviridae, and Totiviridae. The identification of a flavivirus infecting Anopheles mosquitoes broadens our understanding of the evolution and host range of this virus family. This study increases our understanding of virus diversity in general, begins to define the virome of a medically important vector in its natural setting, and lays groundwork for future studies examining the potential impact of these viruses on anopheles biology and disease transmission.<br /> (Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Amino Acid Sequence
Animals
Biodiversity
Burkina Faso
Flavivirus classification
Flavivirus genetics
Genes, Viral
Genome, Viral
Insect Vectors virology
Insect Viruses genetics
Liberia
Metagenome
Metagenomics
Open Reading Frames
Phylogeny
RNA Viruses classification
RNA Viruses genetics
Senegal
Totivirus classification
Totivirus genetics
Anopheles virology
Insect Viruses classification
Microbiota
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0341
- Volume :
- 498
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 27639161
- Full Text :
- https://doi.org/10.1016/j.virol.2016.07.031