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Analysis of Diagnostic Findings From the European Mobile Laboratory in Guéckédou, Guinea, March 2014 Through March 2015.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2016 Oct 15; Vol. 214 (suppl 3), pp. S250-S257. Date of Electronic Publication: 2016 Sep 16. - Publication Year :
- 2016
-
Abstract
- Background: A unit of the European Mobile Laboratory (EMLab) consortium was deployed to the Ebola virus disease (EVD) treatment unit in Guéckédou, Guinea, from March 2014 through March 2015.<br />Methods: The unit diagnosed EVD and malaria, using the RealStar Filovirus Screen reverse transcription-polymerase chain reaction (RT-PCR) kit and a malaria rapid diagnostic test, respectively.<br />Results: The cleaned EMLab database comprised 4719 samples from 2741 cases of suspected EVD from Guinea. EVD was diagnosed in 1231 of 2178 hospitalized patients (57%) and in 281 of 563 who died in the community (50%). Children aged <15 years had the highest proportion of Ebola virus-malaria parasite coinfections. The case-fatality ratio was high in patients aged <5 years (80%) and those aged >74 years (90%) and low in patients aged 10-19 years (40%). On admission, RT-PCR analysis of blood specimens from patients who died in the hospital yielded a lower median cycle threshold (Ct) than analysis of blood specimens from survivors (18.1 vs 23.2). Individuals who died in the community had a median Ct of 21.5 for throat swabs. Multivariate logistic regression on 1047 data sets revealed that low Ct values, ages of <5 and ≥45 years, and, among children aged 5-14 years, malaria parasite coinfection were independent determinants of a poor EVD outcome.<br />Conclusions: Virus load, age, and malaria parasite coinfection play a role in the outcome of EVD.<br /> (© The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Clinical Laboratory Services
Ebolavirus genetics
Female
Filoviridae
Filoviridae Infections complications
Filoviridae Infections virology
Guinea
Hemorrhagic Fever, Ebola complications
Hemorrhagic Fever, Ebola virology
Humans
Infant
Malaria parasitology
Male
Middle Aged
RNA, Viral blood
Viral Load
Young Adult
Ebolavirus isolation & purification
Epidemics
Filoviridae Infections diagnosis
Hemorrhagic Fever, Ebola diagnosis
Malaria complications
Mobile Health Units
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 214
- Issue :
- suppl 3
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 27638946
- Full Text :
- https://doi.org/10.1093/infdis/jiw269