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Volume of Plasma Expansion and Functional Outcomes in Stroke.
- Source :
-
Neurocritical care [Neurocrit Care] 2017 Apr; Vol. 26 (2), pp. 191-195. - Publication Year :
- 2017
-
Abstract
- Background: Plasma expansion in acute ischemic stroke has potential to improve cerebral perfusion, but the long-term effects on functional outcome are mixed in prior trials. The goal of this study was to evaluate how the magnitude of plasma expansion affects neurological recovery in acute stroke.<br />Methods: This was a secondary analysis of data from the Albumin in Acute Stroke Part 2 trial investigating the relationship between the magnitude of overall intravenous volume infusion (crystalloid and colloid) to clinical outcome. The data were inclusive of 841 patients with a mean age of 64 years and a median National Institutes of Health Stroke Scale (NIHSS) of 11. In a multivariable-adjusted logistic regression model, this analysis tested the volume of plasma expansion over the first 48 h of hospitalization as a predictor of favorable outcome, defined as either a modified Rankin Scale score of 0 or 1 or a NIHSS score of 0 or 1 at 90 days. This model included all study patients, irrespective of albumin or isotonic saline treatment.<br />Results: Patients that received higher volumes of plasma expansion more frequently had large vessel ischemic stroke and higher NIHSS scores. The multivariable-adjusted model revealed that there was decreased odds of a favorable outcome for every 250 ml additional volume plasma expansion over the first 48 h (OR 0.91, 95 % CI, 0.88-0.94).<br />Conclusions: The present study demonstrates an association between greater volume of plasma expansion and worse neurological recovery.
Details
- Language :
- English
- ISSN :
- 1556-0961
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Neurocritical care
- Publication Type :
- Academic Journal
- Accession number :
- 27629275
- Full Text :
- https://doi.org/10.1007/s12028-016-0316-0