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Toxicity assessment of anatase and rutile titanium dioxide nanoparticles: The role of degradation in different pH conditions and light exposure.
- Source :
-
Toxicology in vitro : an international journal published in association with BIBRA [Toxicol In Vitro] 2016 Dec; Vol. 37, pp. 201-210. Date of Electronic Publication: 2016 Sep 10. - Publication Year :
- 2016
-
Abstract
- Titanium dioxide nanoparticles (TiO <subscript>2</subscript> NPs), in the two crystalline forms, rutile and anatase, have been widely used in many industrial fields, especially in cosmetics. Therefore, a lot of details about their safety issues have been discussed by the scientific community. Many studies have led to a general agreement about TiO <subscript>2</subscript> NPs toxicity, in particular for anatase form, but no mechanism details have been proved yet. In this study, data confirm the different toxic potential of rutile and anatase TiO <subscript>2</subscript> NPs in two cell lines up to 5nM nanoparticles concentration. Moreover, we evaluated the role of titanium ions released by TiO <subscript>2</subscript> NPs in different conditions, at pH=4.5 (the typical lysosomal compartment pH) and at pH=5.5 (the skin physiological pH) in conditions of darkness and light, to mimic the dermal exposure of cosmetics. Anatase nanoparticles were proner to degradation both in the acidic conditions and at skin pH. Our study demonstrates that pH and sunlight are dominant factors to induce oxidative stress, TiO <subscript>2</subscript> NPs degradation and toxicity effects.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- A549 Cells
Caspase 3 metabolism
Humans
Hydrogen-Ion Concentration
L-Lactate Dehydrogenase metabolism
MCF-7 Cells
Membrane Potential, Mitochondrial drug effects
Metal Nanoparticles chemistry
Metal Nanoparticles radiation effects
Oxidative Stress
Sunlight
Titanium chemistry
Titanium radiation effects
Metal Nanoparticles toxicity
Titanium toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1879-3177
- Volume :
- 37
- Database :
- MEDLINE
- Journal :
- Toxicology in vitro : an international journal published in association with BIBRA
- Publication Type :
- Academic Journal
- Accession number :
- 27622577
- Full Text :
- https://doi.org/10.1016/j.tiv.2016.09.010