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Effect of Bilateral Prefrontal rTMS on Left Prefrontal NAA and Glx Levels in Schizophrenia Patients with Predominant Negative Symptoms: An Exploratory Study.
- Source :
-
Brain stimulation [Brain Stimul] 2017 Jan - Feb; Vol. 10 (1), pp. 59-64. Date of Electronic Publication: 2016 Aug 05. - Publication Year :
- 2017
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Abstract
- Background: Prefrontal repetitive Transcranial Magnetic Stimulation (rTMS) may improve negative symptoms in patients with schizophrenia, but few studies have investigated the underlying neural mechanism.<br />Objective: This study aims to investigate changes in the levels of glutamate and glutamine (Glx, neurotransmitter and precursor) and N-Acetyl Aspartate (NAA) in the left dorsolateral prefrontal cortex of patients with schizophrenia treated with active bilateral prefrontal rTMS as compared to sham-rTMS, as measured with <superscript>1</superscript> H-Magnetic Resonance Spectroscopy ( <superscript>1</superscript> H-MRS).<br />Methods: Patients were randomized to a 3-week course of active or sham high-frequency rTMS. Pre-treatment and post-treatment <superscript>1</superscript> H-MRS data were available for 24 patients with schizophrenia with moderate to severe negative symptoms (Positive and Negative Syndrome Scale (PANSS) negative subscale ≥ 15). Absolute metabolite concentrations were calculated using LCModel with the water peak as reference. To explore the association between treatment condition and changes in concentration of Glx and NAA, we applied a linear regression model.<br />Results: We observed an increase of Glx concentration in the active treatment group and a decrease of Glx concentration in the group receiving sham treatment. The association between changes in Glx concentration and treatment condition was significant. No significant associations between changes in NAA and treatment condition were found.<br />Conclusions: Noninvasive neurostimulation with high-frequency bilateral prefrontal rTMS may influence Glx concentration in the prefrontal cortex of patients with schizophrenia. Larger studies are needed to confirm these findings and further elucidate the underlying neural working mechanism of rTMS.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aspartic Acid metabolism
Double-Blind Method
Female
Humans
Magnetic Resonance Imaging methods
Male
Middle Aged
Schizophrenia diagnostic imaging
Schizophrenia therapy
Treatment Outcome
Young Adult
Aspartic Acid analogs & derivatives
Glutamic Acid metabolism
Pessimism
Prefrontal Cortex metabolism
Schizophrenia metabolism
Transcranial Magnetic Stimulation methods
Subjects
Details
- Language :
- English
- ISSN :
- 1876-4754
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brain stimulation
- Publication Type :
- Academic Journal
- Accession number :
- 27615793
- Full Text :
- https://doi.org/10.1016/j.brs.2016.08.002