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In utero alcohol effects on foetal, neonatal and childhood lung disease.
- Source :
-
Paediatric respiratory reviews [Paediatr Respir Rev] 2017 Jan; Vol. 21, pp. 34-37. Date of Electronic Publication: 2016 Aug 19. - Publication Year :
- 2017
-
Abstract
- Maternal alcohol use during pregnancy exposes both premature and term newborns to the toxicity of alcohol and its metabolites. Foetal alcohol exposure adversely effects the lung. In contrast to the adult "alcoholic lung" phenotype, an inability to identify the newborn exposed to alcohol in utero has limited our understanding of its effect on adverse pulmonary outcomes. This paper will review advances in biomarker development of in utero alcohol exposure. We will highlight the current understanding of in utero alcohol's toxicity to the developing lung and immune defense. Finally, we will present recent clinical evidence describing foetal alcohol's association with adverse pulmonary outcomes including bronchopulmonary dysplasia, viral infections such as respiratory syncytial virus and allergic asthma/atopy. With research to define alcohol's effect on the lung and translational studies accurately identifying the exposed offspring, the full extent of alcohol's effects on clinical respiratory outcomes of the newborn or child can be determined.<br />Competing Interests: The authors acknowledge that they have no financial disclosures to declare.<br /> (Copyright © 2016 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Alcohol Drinking adverse effects
Alcohol Drinking blood
Asthma epidemiology
Asthma etiology
Biomarkers blood
Bronchopulmonary Dysplasia epidemiology
Bronchopulmonary Dysplasia etiology
Child
Female
Glucuronates blood
Glycerophospholipids blood
Humans
Immune System Diseases etiology
Infant, Newborn
Lung Diseases etiology
Pneumonia, Viral epidemiology
Pneumonia, Viral etiology
Pregnancy
Prenatal Exposure Delayed Effects etiology
Respiratory Hypersensitivity epidemiology
Respiratory Hypersensitivity etiology
Respiratory Syncytial Virus Infections epidemiology
Respiratory Syncytial Virus Infections etiology
Sulfuric Acid Esters blood
Alcohol Drinking epidemiology
Immune System Diseases epidemiology
Lung embryology
Lung Diseases epidemiology
Prenatal Exposure Delayed Effects epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-0550
- Volume :
- 21
- Database :
- MEDLINE
- Journal :
- Paediatric respiratory reviews
- Publication Type :
- Academic Journal
- Accession number :
- 27613232
- Full Text :
- https://doi.org/10.1016/j.prrv.2016.08.006