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Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2016 Sep 15; Vol. 298, pp. 82-9. Date of Electronic Publication: 2016 Jul 07. - Publication Year :
- 2016
-
Abstract
- Clinically isolated syndrome (CIS) is a first, usually recovering, episode of neurological disturbance(s) suggestive of multiple sclerosis (MS). CIS subjects might benefit from early disease-modifying drugs, provided that those at high risk of developing MS can be identified. Gene expression for dopaminergic receptors (DR) and adrenoceptors (AR) is dysregulated in lymphocytes of MS patients and is affected by treatment with interferon (IFN)-β. In particular, lymphocyte DR D5 mRNA might be a marker of IFN-β response in MS patients. No information exists so far in CIS subjects. We investigated DR and AR gene expression in peripheral blood mononuclear cells (PBMC) and in CD4+ T effector (Teff) and regulatory (Treg) cells from CIS subjects, and assessed their relationship with MS progression after 12months. Expression of several DR and AR are upregulated in PBMC, Teff and Treg from CIS subjects. DR D3 and α2A-AR mRNA in PBMC, and DR D5 mRNA in Treg correlate with the risk of MS at 12months. Results show the involvement of dopaminergic and adrenergic pathways in CIS as well as in MS pathogenesis, supporting the evaluation of dopaminergic and adrenergic agents in MS.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Catecholamines urine
Disability Evaluation
Disease Progression
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Multiple Sclerosis blood
Multiple Sclerosis diagnostic imaging
Multiple Sclerosis urine
RNA, Messenger metabolism
Receptors, Adrenergic genetics
Receptors, Dopamine genetics
Signal Transduction physiology
Statistics, Nonparametric
Tyrosine 3-Monooxygenase genetics
Tyrosine 3-Monooxygenase metabolism
Young Adult
Lymphocytes metabolism
Multiple Sclerosis pathology
Receptors, Adrenergic metabolism
Receptors, Dopamine metabolism
Up-Regulation physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 298
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 27609280
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2016.07.008