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Epidemiology and pathology of Paget's disease of bone - a review.
- Source :
-
Wiener medizinische Wochenschrift (1946) [Wien Med Wochenschr] 2017 Feb; Vol. 167 (1-2), pp. 2-8. Date of Electronic Publication: 2016 Sep 06. - Publication Year :
- 2017
-
Abstract
- Paget's disease of bone (PDB) is a noninflammatory, metabolic, skeletal disorder characterized by localized excessive osteoclastic bone resorption that is followed by compensatory increased osteoblastic activity leading to unstructured, fibroblastic, and biomechanically unstable bone. As a result, there is deformity and enlargement of the bone with a defective and disorganized pattern. Here, we review the epidemiology, etiology, pathology, macrostructure, histology, and quantitative histomorphometry findings of PDB. Hyperosteoclastosis and poor definition of the boundary between cortical and medullary bone are the main histological findings in PDB. Additionally, Pagetic bone is also characterized by hypertrophy and alteration of trabecular parameters.<br />Competing Interests: E. Nebot Valenzuela and P. Pietschmann declare that they have no competing interests.
- Subjects :
- Adult
Aged
Bone Density physiology
Bone Remodeling physiology
Bone Resorption genetics
Bone Resorption physiopathology
Cancellous Bone pathology
Cross-Cultural Comparison
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Osteitis Deformans genetics
Osteoblasts pathology
Osteoclasts pathology
Osteogenesis physiology
Tomography, X-Ray Computed
Bone and Bones pathology
Osteitis Deformans epidemiology
Osteitis Deformans pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1563-258X
- Volume :
- 167
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Wiener medizinische Wochenschrift (1946)
- Publication Type :
- Academic Journal
- Accession number :
- 27600564
- Full Text :
- https://doi.org/10.1007/s10354-016-0496-4