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Association between Fetal Cerebral Ventriculomegaly and Platelet Alloimmunisation.
- Source :
-
Fetal diagnosis and therapy [Fetal Diagn Ther] 2017; Vol. 42 (1), pp. 35-41. Date of Electronic Publication: 2016 Sep 07. - Publication Year :
- 2017
-
Abstract
- Introduction: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare condition that may lead to intracerebral haemorrhage (ICH) in the fetus or neonate. Platelet alloimmunisation causing FNAIT has been described in association with fetal cerebral ventriculomegaly (VM), presumably due to subclinical ICH. The objective of this study was to assess the association between fetal VM and platelet alloimmunisation.<br />Methods: This is a case series of pregnancies with fetal VM screened for platelet alloantibodies from 2003 to 2012. Cases of multiple pregnancies, structural anomalies, aneuploidies, or congenital infection were excluded.<br />Results: Of 45 pregnancies with fetal VM that were screened for platelet alloantibodies, 5 (11%) were positive. There was only one antenatal ICH, with confirmed fetal severe thrombocytopenia before termination of pregnancy. The other cases were treated with intravenous immunoglobulins without prior fetal blood sampling. No other case of neonatal thrombocytopenia was confirmed.<br />Conclusions: The prevalence of platelet alloimmunisation was high in this series of fetal VM. Prospective large studies are needed to confirm the role of platelet alloimmunisation in fetal VM.<br /> (© 2016 S. Karger AG, Basel.)
- Subjects :
- Adult
Cerebral Intraventricular Hemorrhage diagnostic imaging
Cerebral Intraventricular Hemorrhage embryology
Cerebral Intraventricular Hemorrhage etiology
Female
Follow-Up Studies
Humans
Hydrocephalus diagnostic imaging
Hydrocephalus embryology
Hydrocephalus physiopathology
Isoantibodies analysis
Magnetic Resonance Imaging
Male
Maternal Serum Screening Tests
Medical Records
Pregnancy
Prevalence
Retrospective Studies
Switzerland epidemiology
Tertiary Care Centers
Thrombocytopenia, Neonatal Alloimmune epidemiology
Thrombocytopenia, Neonatal Alloimmune etiology
Thrombocytopenia, Neonatal Alloimmune immunology
Ultrasonography, Prenatal
Autoimmunity
Cerebral Intraventricular Hemorrhage prevention & control
Hydrocephalus therapy
Immunoglobulins, Intravenous therapeutic use
Thrombocytopenia, Neonatal Alloimmune prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9964
- Volume :
- 42
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Fetal diagnosis and therapy
- Publication Type :
- Academic Journal
- Accession number :
- 27597992
- Full Text :
- https://doi.org/10.1159/000448994