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gamma-Aminobutyric acid uptake by rat kidney brush-border membrane vesicles.
- Source :
-
Experientia [Experientia] 1989 Aug 15; Vol. 45 (8), pp. 726-8. - Publication Year :
- 1989
-
Abstract
- Brush-border membrane vesicles (BBMV) from rat kidney cortex possessed two uptake systems for gamma-aminobutyric acid (GABA), a high affinity system (Km = 10.9 microM) and a low affinity system (Km = 1203 microM). Both uptake systems were inhibited by p-hydroxymercuribenzoic acid and ouabain, and by the action of neuraminidase, whereas the GABA analogs nipecotic acid, beta-alanine, 2,4-diaminobutyric acid and 4,5,6,7-tetrahydroisoxazolo-[4,5 c]-pyridin-3-ol had no effect on the GABA uptake activity. The BBMV uptake systems were clearly different from the GABA transport systems present in brain tissue.
Details
- Language :
- English
- ISSN :
- 0014-4754
- Volume :
- 45
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Experientia
- Publication Type :
- Academic Journal
- Accession number :
- 2759201
- Full Text :
- https://doi.org/10.1007/BF01974569