Bundling potent natural toxin cantharidin within platinum (IV) prodrugs for liposome drug delivery and effective malignant neuroblastoma treatment.

Authors :: Yang X
Tong J
Guo L
Qian Z
Chen Q
Qi R
Qiu Y
Source :: Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2017 Jan; Vol. 13 (1), pp. 287-296. Date of Electronic Publication: 2016 Aug 31.
Publication Year :: 2017
Abstract: Neuroblastoma (NB) is one of the most commonly seen malignancies in childhood and infancy. Cantharidin is a highly potent natural toxin that possesses potent anti-tumor properties on various cancers including NB. However, exposure to cantharidin can cause severe chemical burns and application of cantharidin for cancer therapy is limited. Here we report a strategy of bundling cantharidin within a hybrid platinum (IV) prodrug conjugate. This hydrophobic drug conjugate, ie, CanPt can be further formulated into liposome for drug delivery to minimize the exposure of cantharidin to normal cells for efficient chemotherapeutic agent against NB.<br /> (Copyright © 2016 Elsevier Inc. All rights reserved.)

Subjects :: Animals
Cell Line, Tumor
Drug Liberation
Drug Screening Assays, Antitumor
Female
Mice
Mice, Inbred BALB C
Nanoconjugates chemistry
Cantharidin administration & dosage
Drug Carriers chemistry
Liposomes chemistry
Neuroblastoma drug therapy
Platinum administration & dosage
Prodrugs administration & dosage

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