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Cassane-type diterpenes from Caesalpinia minax induce apoptosis in pituitary adenoma: structure-activity relationship, ER stress and Wnt/β-catenin pathways.
- Source :
-
Journal of Asian natural products research [J Asian Nat Prod Res] 2017 May; Vol. 19 (5), pp. 423-435. Date of Electronic Publication: 2016 Sep 02. - Publication Year :
- 2017
-
Abstract
- Plant-derived natural products have been the highly significant sources of novel antitumor agents. The cassane-type diterpenes of genus Caesalpinia have been reported to bear antiproliferative activities toward different types of cancer cells. In this study, we evaluated the antineoplasmic activities of 16 natural origin cassane-type diterpenes isolated from the CHCl <subscript>3</subscript> extract of the seeds of C. minax in pituitary adenomas cells and identified caesalpin G (CAG) showed the strongest cytotoxicity. Moreover, we further investigated the structure-activity relationship and molecular mechanism of these derivatives systematically. The results confirmed the unsaturated lactone-type ring, hydroxyl at C-7, and alkenyl at C-11 or C-14 functionality as critical for anticancer activity in this family of natural products. In addition, the mechanism experiments also demonstrated unfolded protein response and ER stress and Wnt/β-catenin pathway were involved in the CAG-induced apoptosis.
- Subjects :
- Antineoplastic Agents chemistry
Apoptosis drug effects
Diterpenes chemistry
Drug Screening Assays, Antitumor
Drugs, Chinese Herbal chemistry
Drugs, Chinese Herbal isolation & purification
Humans
Molecular Structure
Pituitary Neoplasms drug therapy
Seeds chemistry
Structure-Activity Relationship
Wnt Proteins drug effects
beta Catenin drug effects
Antineoplastic Agents isolation & purification
Antineoplastic Agents pharmacology
Caesalpinia chemistry
Diterpenes isolation & purification
Diterpenes pharmacology
Drugs, Chinese Herbal pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2213
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of Asian natural products research
- Publication Type :
- Academic Journal
- Accession number :
- 27588605
- Full Text :
- https://doi.org/10.1080/10286020.2016.1217520