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Nestin(+) cells direct inflammatory cell migration in atherosclerosis.
- Source :
-
Nature communications [Nat Commun] 2016 Sep 02; Vol. 7, pp. 12706. Date of Electronic Publication: 2016 Sep 02. - Publication Year :
- 2016
-
Abstract
- Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestin(+) cells cooperate with endothelial cells in directing monocyte egress to bloodstream in response to infections. However, it remains unknown whether nestin(+) cells regulate inflammatory cells in chronic inflammatory diseases, such as atherosclerosis. Here, we show that nestin(+) cells direct inflammatory cell migration during chronic inflammation. In Apolipoprotein E (ApoE) knockout mice fed with high-fat diet, BM nestin(+) cells regulate the egress of inflammatory monocytes and neutrophils. In the aorta, nestin(+) stromal cells increase ∼30 times and contribute to the atheroma plaque. Mcp1 deletion in nestin(+) cells-but not in endothelial cells only- increases circulating inflammatory cells, but decreases their aortic infiltration, delaying atheroma plaque formation and aortic valve calcification. Therefore, nestin expression marks cells that regulate inflammatory cell migration during atherosclerosis.
- Subjects :
- Animals
Aorta cytology
Aorta pathology
Apolipoproteins E genetics
Diet, High-Fat
Inflammation pathology
Mesoderm pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Monocytes immunology
Neutrophils immunology
Plaque, Atherosclerotic pathology
Atherosclerosis pathology
Cell Movement physiology
Chemokine CCL2 genetics
Endothelial Cells pathology
Mesoderm cytology
Nestin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 27586429
- Full Text :
- https://doi.org/10.1038/ncomms12706