Back to Search
Start Over
A 90-day oral (dietary) toxicity and mass balance study of corn starch fiber in Sprague Dawley rats.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2016 Nov; Vol. 97, pp. 57-69. Date of Electronic Publication: 2016 Aug 28. - Publication Year :
- 2016
-
Abstract
- The potential toxicity of corn starch fiber was assessed and compared to polydextrose, a commonly used bulking agent with a long history of safe use in the food supply. Groups of male and female Crl:CD(SD) rats were fed 0 (control), 1,000, 3,000, or 10,000 mg/kg-bw/day corn starch fiber in the diet for 90 days. The polydextrose reference article was offered on a comparable regimen at 10,000 mg/kg-bw/day. Following a single gavage dose of [ <superscript>14</superscript> C]-corn starch fiber on study day 13 or 90, the mass balance of the test article was assessed by analysis of excreta samples collected from 0 to 168 h post-dose. There were no toxicologically or biologically relevant findings in any of the test article-treated groups. The few minor differences observed between the corn starch fiber and polydextrose exposed groups were considered to be due to normal biological variation. Following [ <superscript>14</superscript> C]-corn starch fiber dosing, nearly complete excretion of the administered dose occurred over 168 h post-dosing, with the majority excreted in the feces. The dietary no-observed-adverse-effect level of corn starch fiber after 90 days was 10,000 mg/kg-bw/day. Similar toxicity profiles for corn starch fiber and polydextrose were observed due to the structural and compositional similarities of these materials.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Administration, Oral
Animals
Dietary Fiber administration & dosage
Dose-Response Relationship, Drug
Female
Food Additives administration & dosage
Food Additives toxicity
Glucans administration & dosage
Glucans toxicity
Male
No-Observed-Adverse-Effect Level
Rats
Rats, Sprague-Dawley
Starch administration & dosage
Carbon Radioisotopes analysis
Dietary Fiber toxicity
Feces chemistry
Starch toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 97
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 27580979
- Full Text :
- https://doi.org/10.1016/j.fct.2016.08.030