Back to Search
Start Over
Global phylogeography and evolutionary history of Shigella dysenteriae type 1.
- Source :
-
Nature microbiology [Nat Microbiol] 2016 Mar 21; Vol. 1, pp. 16027. Date of Electronic Publication: 2016 Mar 21. - Publication Year :
- 2016
-
Abstract
- Together with plague, smallpox and typhus, epidemics of dysentery have been a major scourge of human populations for centuries(1). A previous genomic study concluded that Shigella dysenteriae type 1 (Sd1), the epidemic dysentery bacillus, emerged and spread worldwide after the First World War, with no clear pattern of transmission(2). This is not consistent with the massive cyclic dysentery epidemics reported in Europe during the eighteenth and nineteenth centuries(1,3,4) and the first isolation of Sd1 in Japan in 1897(5). Here, we report a whole-genome analysis of 331 Sd1 isolates from around the world, collected between 1915 and 2011, providing us with unprecedented insight into the historical spread of this pathogen. We show here that Sd1 has existed since at least the eighteenth century and that it swept the globe at the end of the nineteenth century, diversifying into distinct lineages associated with the First World War, Second World War and various conflicts or natural disasters across Africa, Asia and Central America. We also provide a unique historical perspective on the evolution of antibiotic resistance over a 100-year period, beginning decades before the antibiotic era, and identify a prevalent multiple antibiotic-resistant lineage in South Asia that was transmitted in several waves to Africa, where it caused severe outbreaks of disease.
- Subjects :
- Drug Resistance, Bacterial
Dysentery, Bacillary history
Genome, Bacterial
Global Health
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Molecular Epidemiology
Sequence Analysis, DNA
Shigella dysenteriae genetics
Dysentery, Bacillary epidemiology
Dysentery, Bacillary microbiology
Evolution, Molecular
Phylogeography
Serogroup
Shigella dysenteriae classification
Shigella dysenteriae isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 2058-5276
- Volume :
- 1
- Database :
- MEDLINE
- Journal :
- Nature microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 27572446
- Full Text :
- https://doi.org/10.1038/nmicrobiol.2016.27