Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole against a Collection of Azole-Resistant and -Susceptible Aspergillus fumigatus Strains.

Authors :: Abastabar M
Rahimi N
Meis JF
Aslani N
Khodavaisy S
Nabili M
Rezaei-Matehkolaei A
Makimura K
Badali H
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Oct 21; Vol. 60 (11), pp. 6916-6919. Date of Electronic Publication: 2016 Oct 21 (Print Publication: 2016).
Publication Year :: 2016
Abstract: A collection of azole-susceptible (n = 141) and azole-resistant (n = 27) Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC <subscript>90</subscript> values for the azole-susceptible strains were 0.001 μg/ml and 0.008 μg/ml, and those for the azole-resistant strains were 0.016 μg/ml and 0.032 μg/ml.<br /> (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)

Subjects :: Aspergillus fumigatus genetics
Aspergillus fumigatus isolation & purification
Azoles pharmacology
Humans
Microbial Sensitivity Tests
Antifungal Agents pharmacology
Aspergillus fumigatus drug effects
Drug Resistance, Fungal drug effects
Imidazoles pharmacology

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