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Lipid Accumulation Product (LAP) and Visceral Adiposity Index (VAI) as Markers of Insulin Resistance and Metabolic Associated Disturbances in Young Argentine Women with Polycystic Ovary Syndrome.
- Source :
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Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme [Horm Metab Res] 2017 Jan; Vol. 49 (1), pp. 23-29. Date of Electronic Publication: 2016 Aug 29. - Publication Year :
- 2017
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Abstract
- Polycystic ovary syndrome (PCOS) is an endocrine disorder. PCOS women are at high risk of developing insulin resistance (IR) and cardiovascular disorders since young age. We aimed to study the reliability of lipid accumulation product (LAP) and visceral adiposity index (VAI) as markers of metabolic disturbances (MD) associated with IR in young reproductive aged PCOS patients. We also evaluated the association between LAP and VAI and the presence of hyperandrogenism. In a cross-sectional study, 110 PCOS patients and 88 control women (18-35 years old) were recruited. PCOS patients were divided into 2 groups, as hyperandrogenic and non-hyperandrogenic considering the signs of hyperandrogenism (clinical or biochemical). Anthropometric measurements were taken and blood samples collected. Metabolic and anthropometric characteristics and their association with IR and associated MD were evaluated and LAP and VAI were calculated. LAP and VAI were compared with TC/HDL-c and TG/HDL-c to define the best markers of MD in this population. Independently of the phenotype, young PCOS patients showed high IR and dyslipidemia. Both LAP and VAI showed to be more effective markers to assess MD and IR in these young women than TG/HDL-c or TC/HDL-c [cut-off values: LAP: 18.24 (sensitivity: 81.43% specificity: 73.49%), positive predictive value (PPV): 75.0%, negative predictive value (NPV): 77.27%, VAI: 2.19 (sensitivity: 81.16% specificity: 72.15% PPV: 74.65% NPV: 72.22%)]. LAP and VAI are representative markers to assess MD associated with IR in young PCOS patients. All PCOS patients, independently of their androgenic condition, showed high metabolic risk.<br /> (© Georg Thieme Verlag KG Stuttgart · New York.)
- Subjects :
- Adiposity physiology
Adolescent
Adult
Argentina
Cross-Sectional Studies
Female
Humans
Metabolic Diseases diagnosis
Metabolic Diseases etiology
Metabolic Diseases pathology
Obesity, Abdominal complications
Obesity, Abdominal diagnosis
Obesity, Abdominal metabolism
Obesity, Abdominal pathology
Polycystic Ovary Syndrome diagnosis
Polycystic Ovary Syndrome metabolism
Polycystic Ovary Syndrome pathology
Predictive Value of Tests
Reproducibility of Results
Sagittal Abdominal Diameter
Young Adult
Biomarkers metabolism
Insulin Resistance
Intra-Abdominal Fat pathology
Lipid Accumulation Product
Metabolic Diseases complications
Polycystic Ovary Syndrome complications
Subjects
Details
- Language :
- English
- ISSN :
- 1439-4286
- Volume :
- 49
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
- Publication Type :
- Academic Journal
- Accession number :
- 27571188
- Full Text :
- https://doi.org/10.1055/s-0042-113463